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5 from 4 votes

Southern Breakfast Casserole Recipe

Southern Breakfast Casserole Recipe - Filled with eggs, sausage, cheese, and tender buttermilk biscuits, this makes the perfect breakfast! Made even easier as a make ahead breakfast casserole, it will quickly become a family favorite!
Prep Time15 mins
Cook Time40 mins
Total Time55 mins
Course: Breakfast
Cuisine: American
Keyword: breakfast casserole recipe, easy breakfast casserole recipe, make ahead breakfast casserole recipe, southern breakfast casserole recipe
Servings: 10
Calories: 313kcal
Author: Robyn Stone | Add a Pinch


  • 1 pound breakfast sausage
  • 1/2 medium onion diced
  • 1 clove garlic diced
  • 4-6 baked buttermilk biscuits cubed
  • 2 cups whole milk or half and half
  • 8 large eggs beaten
  • 1 cup shredded cheddar cheese
  • 1/2 teaspoon salt
  • 1/2 teaspoon black pepper
  • 1/2 teaspoon dry mustard


  • Spray 9x13 casserole dish with nonstick cooking spray and set aside.
  • Crumble sausage in a medium skillet with onion and garlic. Cook over medium heat until the sausage is browned and cooked through and the onion is tender. Drain and set aside.
  • Arrange bread cubes in bottom of prepared casserole dish.
  • Stir together sausage mixture, milk, eggs, cheese, salt, pepper, and dry mustard and pour over cubed biscuits. Cover tightly and refrigerate overnight up to two days.
  • Preheat oven to 350ยบ F and bake for 40-45 minutes, until center of casserole is just set. Allow to stand for about 10 minutes before serving.


Calories: 313kcal | Carbohydrates: 8g | Protein: 17g | Fat: 22g | Saturated Fat: 8g | Cholesterol: 198mg | Sodium: 654mg | Potassium: 275mg | Sugar: 3g | Vitamin A: 440IU | Vitamin C: 0.8mg | Calcium: 170mg | Iron: 1.6mg